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Effect of biased agonism on OR desensitization The first reports describing a differential desensitization of MOR, DOR, and KOR by various agonists came from Reisine's group (Blake et al., Biased agonism at MOR and desensitization Functional studies revealed that [D-Ala 2 -MePhe 4 -Gly 5 -ol]enkephalin (DAMGO) induced a stronger desensitization of MOR than morphine in different experimental models and signaling pathways (Yu et al., 1997

Importantly, those receiving lutein plus zeaxanthin did not experience a significantly higher risk of lung cancer as seen with beta-carotene, suggesting lutein plus zeaxanthin is an appropriate and effective replacement for beta-carotene in the AREDS2 formula

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Modig K Article: JOURNAL OF INTERNAL MEDICINE

Kang H, Park CH, Kwon SO, Lee SG (2023) ED Formula, a complex of ecklonia cava and chrysanthemum indicum, ameliorates airway inflammation in lipopolysaccharide-stimulated RAW macrophages and ovalbumin-induced asthma mouse model

(Liu is on scientific advisory board of the University of Oxfords Jenner Institute, which developed AstraZenecas vaccine for COVID-19.) Had this to say in The Scientist